Tanta University · 2026 AKI in Advanced Cirrhosis in Egypt

Systematic Review & Meta-Analysis Protocol

Prevalence and Risk Factors of Acute Kidney Injury in Patients with Advanced Cirrhosis in Egypt

A structured protocol package with linked full texts, screening notes, retrieval status, source verification, and an evidence map drawn from 51 screened records.

By Mohamed Zakaria Elsayed Shehata, M.B.B.Ch, 2021 — Tanta University

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    At a glance

    Screening package summary

    Methodology at a glance

    How this evidence is being appraised

    The review framework, statistical model and risk-of-bias strategy — pulled directly from the protocol so the appraisal logic is transparent before a single estimate is pooled.

    P

    Statistical model

    • Random-effects pooling (DerSimonian–Laird / REML)
    • Freeman–Tukey double-arcsine transform for proportions
    • Logit transform in sensitivity analysis
    • Pooled prevalence & 95% CI as the primary outcome
    I²

    Heterogeneity

    • Cochran’s Q test for statistical heterogeneity
    • I² (>50% = substantial), between-study variance τ²
    • 95% prediction interval alongside the pooled estimate
    • Subgroup analysis by criteria, design, setting, etiology, severity
    JBI

    Risk of bias

    • JBI checklist for prevalence data (primary outcome)
    • Newcastle–Ottawa Scale for cohort / case–control (RF estimates)
    • Two independent reviewers; disagreements by a third
    • Leave-one-out analysis + exclusion of high-risk studies
    PB

    Publication bias & certainty

    • Funnel-plot symmetry (≥10 studies)
    • Egger’s regression for small-study effects
    • GRADE approach with Summary of Findings table
    • Random-effects meta-regression (≥10 studies)

    Projected pooled estimate

    Random-effects pooled prevalence — schematic

    Illustrative preview of the analysis format. Actual estimates will appear once screening completes.
    0% 15% 30% 45% 60% 75% Study A (2021) Study B (2022) Study C (2023) Study D (2024) Study E (2025) Pooled estimate (95% CI)

    Evidence Insights

    Quantitative view of the screening set

    Live distributions computed directly from the linked screening records — retrieval status, evidence tiers, study designs, publication timeline, and geographic origin.

    Retrieval status

    Full-text availability across 51 records

    Evidence tiers

    Inclusion role per record

    Study design

    Methodological mix

    Publication timeline

    Records per year (2011–2026)

    Geographic origin

    Egypt vs comparator regions

    PRISMA 2020 Flow

    Screening & selection process

    A prospective record of how 51 records are being moved through identification, screening, eligibility, and inclusion following the PRISMA 2020 statement.

      Inter-reviewer agreement will be quantified using Cohen’s kappa; disagreements resolved by a third reviewer. The completed review will report a PRISMA 2020 flow diagram.

      Protocol

      Protocol

      Under Supervision of

      الملخص العربي

      References

      Cited literature

        Evidence Map

        Screening set structure

        Paper Library

        Linked screening table

        No. Tier Study Year Status Links